abstract：:Prevalence of MODY2 and MODY3 mutations has been assessed in 23 Brazilian families with MODY phenotype. Mutations in HNF-1alpha have been found in 3 families (13%) and 2 families (8.7%) had new glucokinase mutations. These genes do not explain the majority of MODY cases in Brazilian population. ...

journal_title：Diabetes research and clinical practice

authors： Furuzawa GK,Giuffrida FM,Oliveira CS,Chacra AR,Dib SA,Reis AF

更新日期：2008-09-01 00:00:00

abstract：:Coated-platelet levels were quantified in 58 people with Type 1 diabetes, 90 with Type 2 diabetes, and 54 non-diabetic controls. In diabetes high coated-platelet levels were related to smoking and glucose control drugs, but not to glycaemia or other drugs. Prospective studies should evaluate coated-platelets and compl...

journal_title：Diabetes research and clinical practice

authors： Jenkins AJ,Gosmanova AK,Lyons TJ,May KD,Dashti A,Baker MZ,Olansky L,Aston CE,Dale GL

更新日期：2008-08-01 00:00:00

abstract：:We examined the preventive effect of Momordica charantia L. fruit (bitter melon) on hyperglycemia and insulin resistance in C57BL/6J mice fed with a high-fat (HF) diet. Firstly, mice were divided randomly into two groups: the control group was fed low-fat (LF) diet, whereas the experimental group was fed with a 45% HF...

journal_title：Diabetes research and clinical practice

authors： Shih CC,Lin CH,Lin WL

更新日期：2008-08-01 00:00:00

abstract：:Serum pigment epithelium-derived factor (PEDF) levels were significantly higher in type 1 diabetic patients with retinopathy (n=20, 10.38+/-3.87 microg/ml) compared to the patients without it (n=57, 7.68+/-2.80 microg/ml) (p=0.0013). Elevated PEDF levels may be related to the progression of diabetic retinopathy. ...

journal_title：Diabetes research and clinical practice

authors： Katakami N,Kaneto H,Yamasaki Y,Matsuhisa M

更新日期：2008-07-01 00:00:00

abstract：:We investigated the incidence of the slowly progressive form of type 1 diabetes (SPT1D) detected by the urine glucose-screening tests at schools in the Tokyo Metropolitan Area from 1974 to 2004. During this study period, a total of 9,242,259 school students underwent the screening program. Of them, 54 children, 19 mal...

journal_title：Diabetes research and clinical practice

authors： Urakami T,Suzuki J,Yoshida A,Saito H,Mugishima H

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Although several antibiotics have been studied for the treatment of foot infections, their effectiveness has been considered to be similar. The scope of this analysis was the identification of factors that are associated with treatment failure based on evidence from randomized controlled trials (RCTs). METH...

journal_title：Diabetes research and clinical practice

authors： Vardakas KZ,Horianopoulou M,Falagas ME

更新日期：2008-06-01 00:00:00

abstract：AIMS:Evidence suggests that chronic hyperglycaemia predicts not only microvascular disease but also macrovascular disease, however it is not known whether it is the glucose variability per se or the total glucose exposure that confers risk. The objective of this study was to investigate whether daily glucose variabilit...

journal_title：Diabetes research and clinical practice

authors： Gordin D,Rönnback M,Forsblom C,Mäkinen V,Saraheimo M,Groop PH

更新日期：2008-06-01 00:00:00

abstract：:An increase in capillary filtration of albumin (CFA) is well demonstrated in diabetes. Statins may exert a protective effect against endothelial dysfunction. The aim of this study was to test whether rosuvastatin may prevent the increase in peripheral CFA in diabetic rats and the role of blood pressure lowering. Rats ...

journal_title：Diabetes research and clinical practice

authors： Tarhzaoui K,Valensi P,Boulakia FC,Lestrade R,Albertini JP,Behar A

更新日期：2008-06-01 00:00:00

abstract：:Many studies show poor agreement between fasting plasma glucose (FPG)-based and 2-h postchallenge glucose (2-h PG)-based criteria to assess glucose metabolism. We examined the rate of agreement between FPG- and 2-h PG-based criteria in the diagnosis of intermediate hyperglycemia in four representative cohort studies i...

journal_title：Diabetes research and clinical practice

authors： Oh JY,Lim S,Kim DJ,Kim NH,Kim DJ,Moon SD,Jang HC,Cho YM,Song KH,Ahn CW,Sung YA,Park JY,Shin C,Lee HK,Park KS,Committee of the Korean Diabetes Association on the Diagnosis and Classification of Diabetes Mellitus.

更新日期：2008-06-01 00:00:00

abstract：AIM:To evaluate the relationship of plasma endothelin-1 (ET-1) levels, a marker of endothelial dysfunction, and urinary albumin excretion in patients with type 2 diabetes mellitus (DM). METHODS:Cross-sectional study was conducted in 279 patients (132 males, mean age: 58.7+/-11.0 years, mean DM duration: 11.3+/-8.1 yea...

journal_title：Diabetes research and clinical practice

authors： Zanatta CM,Gerchman F,Burttet L,Nabinger G,Jacques-Silva MC,Canani LH,Gross JL

更新日期：2008-05-01 00:00:00

abstract：AIMS:To compare the ability of definitions of Metabolic Syndrome (MetS) in the prediction of type 2 diabetes. METHODS:We examined 4756 subjects in an Iranian population who were non-diabetic at baseline. After 3.6 years, 188 individuals developed diabetes. RESULTS:Impaired glucose tolerance (IGT) and MetS definitions...

journal_title：Diabetes research and clinical practice

authors： Hadaegh F,Ghasemi A,Padyab M,Tohidi M,Azizi F

更新日期：2008-05-01 00:00:00

abstract：:Insulin resistance (IR) is postulated to underlie diabetes, the metabolic syndrome (MS) and cardiovascular disease (CVD). The D20S32e marker close to the melanocortin receptor-3 (hMC3-R) has been shown to be associated with IR in a large New Zealand Māori kindred, a population at high risk for MS and CVD. Here we exam...

journal_title：Diabetes research and clinical practice

authors： Wong J,Nock NL,Xu Z,Kyle C,Daniels A,White M,Yue DK,Elston RC,Mountjoy KG

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:While CKD is a common finding in patients with type 2 diabetes, the clinical response to its identification is often problematic. This study aims to determine the frequency of albuminuria in patients with type 2 diabetes in the primary care setting and examine the factors which influence its management. MET...

journal_title：Diabetes research and clinical practice

authors： Thomas MC

更新日期：2008-04-01 00:00:00

abstract：:To assess whether plasma retinol-binding protein (RBP) is a marker of insulin resistance we measured RBP, insulin and glucose in 285 fasting subjects attending a Lipid Disorders Clinic as outpatients. They were grouped as either subjects without diabetes mellitus and with varying degrees of insulin resistance or subje...

journal_title：Diabetes research and clinical practice

authors： Lewis JG,Shand BI,Elder PA,Scott RS

更新日期：2008-04-01 00:00:00

abstract：AIM:We report the effectiveness of the thiazolidinedione, pioglitazone, as add-on medication to metformin or sulfonylurea in reducing post-load serum glucose levels, as assessed by 3-h oral glucose tolerance testing (OGTT). METHODS:Adult patients with Type 2 diabetes took part in one of two large-scale, 2-year clinica...

journal_title：Diabetes research and clinical practice

authors： Seufert J,Urquhart R

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To investigate association of psychosocial factors with anxiety and depressive symptoms in Chinese type 2 diabetes patients. METHODS:Three hundred and four type 2 diabetes patients were inquired with a structured questionnaire about socio-demographic characteristics, psychological stress, coping styles, soci...

journal_title：Diabetes research and clinical practice

authors： Zhang CX,Chen YM,Chen WQ

更新日期：2008-03-01 00:00:00

abstract：:Both elevated liver enzymes and a family history of diabetes mellitus (FHDM) are independent risk factors for type 2 diabetes. This study evaluates the epidemiological association between elevated liver enzymes and FHDM. Subjects included 3512 women workers without diabetes, hepatitis, a smoking habit, or a history of...

journal_title：Diabetes research and clinical practice

authors： Inoue K,Matsumoto M,Miyoshi Y,Kobayashi Y

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:We examined the effect of a 14-month progressive resistance training (PRT) program on endothelial function in both a supervised training (Center) group and non-supervised training (Home) group of patients with type 2 diabetes. We studied 28 men and women with type 2 diabetes who participated in a 14-month PRT...

journal_title：Diabetes research and clinical practice

authors： Cohen ND,Dunstan DW,Robinson C,Vulikh E,Zimmet PZ,Shaw JE

更新日期：2008-03-01 00:00:00

abstract：:Insulin administration causes various types of immune response to insulin. However, there have been no reports that insulin administration triggers pancreatic beta-cell destruction in diabetic patients. We evaluated three patients who had suffered from type 2 diabetes or impaired glucose tolerance for 5-30 years. Afte...

journal_title：Diabetes research and clinical practice

authors： Nakamura M,Nishida W,Yamada Y,Chujo D,Watanabe Y,Imagawa A,Hanafusa T,Kawasaki E,Onuma H,Osawa H,Makino H

更新日期：2008-02-01 00:00:00

abstract：:We investigated the preventive effects of ferulic acid (FA) and alpha-tocopherol (AT) on the progression of diabetic nephropathy. Otsuka Long-Evans Tokushima Fatty (OLETF) and Long-Evans Tokushima Otsuka (LETO) rats were used as type 2 diabetes and non-diabetes models, respectively. Two-thirds of the OLETF rats were f...

journal_title：Diabetes research and clinical practice

authors： Fujita A,Sasaki H,Doi A,Okamoto K,Matsuno S,Furuta H,Nishi M,Nakao T,Tsuno T,Taniguchi H,Nanjo K

更新日期：2008-01-01 00:00:00

abstract：:Amelioration of albuminuria may be related to specific constellations of risk factors including race and dyslipidaemia. Circulating cholesterol could mitigate the beneficial effect of antihypertensive therapy. We assessed whether cholesterol affected the remission of urinary albumin in patients with type 2 diabetes of...

journal_title：Diabetes research and clinical practice

authors： Earle KA,Harry D,Zitouni K

更新日期：2008-01-01 00:00:00

abstract：:A new insulin sensitivity index was devised on the basis of an autoregressive model and its validity was investigated. Using data from the 75-g oral glucose tolerance test (OGTT), 115 subjects were divided into 3 groups: 40 with normal glucose tolerance, 34 with impaired glucose tolerance, and 41 with type 2 diabetes ...

journal_title：Diabetes research and clinical practice

authors： Kazama Y,Takamura T,Sakurai M,Shindo H,Ohkubo E,Aida K,Harii N,Taki K,Kaneshige M,Tanaka S,Shimura H,Endo T,Kobayashi T

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of specialized young adult diabetes clinic (YAC) on glycemic control in a young adult patients with type 1 diabetes (DM1) transitioning from pediatric to adult diabetes care. RESEARCH DESIGN AND METHODS:HbA1c was retrospectively analyzed through 3 years in 15-25 y/o DM1 patients enteri...

journal_title：Diabetes research and clinical practice

authors： Lane JT,Ferguson A,Hall J,McElligott M,Miller M,Lane PH,Pfeffer E

更新日期：2007-12-01 00:00:00

abstract：AIMS:To determine the change in prevalence, incidence and risk factors associated with diabetes and impaired fasting glucose (IFG) in a rural Korean area. METHODS:Initially a total of 1119 subjects (424 men and 695 women) aged 31-99 years were recruited in 1997. Baseline clinical data and various laboratory values wer...

journal_title：Diabetes research and clinical practice

authors： Song KH,Nam-Goomg IS,Han SM,Kim MS,Lee EJ,Lee YS,Lee MS,Yoon S,Lee KU,Park JY

更新日期：2007-12-01 00:00:00

abstract：:We sought to examine the changes in the strength-duration time constant (SDTC) of the median nerve in diabetic polyneuropathy. The SDTC is a measure of axonal excitability and depends on the biophysical properties of the axonal membrane. It may provide some information about Na(+) channel functioning. Forty-nine diabe...

journal_title：Diabetes research and clinical practice

authors： Yerdelen D,Koç F,Uysal H,Sarica Y

更新日期：2007-10-01 00:00:00

abstract：:In diabetes, postprandial hyperlipidemia is recognized as a risk factor for premature atherosclerosis and following cardiovascular disease. In the present study, features of fat absorption and clearance were examined to clarify the lipid metabolism of Spontaneously Diabetic Torii (SDT) rats. Olive oil was orally admin...

journal_title：Diabetes research and clinical practice

authors： Sasase T,Morinaga H,Yamamoto H,Ogawa N,Matsui K,Miyajima K,Kawai T,Mera Y,Masuyama T,Shinohara M,Ohta T,Matsushita M

更新日期：2007-10-01 00:00:00

abstract：:Mortality, macroangiopathic events and end-stage renal disease (ESRD) in the elderly under long-term, intensive multifactorial diabetes control were prospectively investigated. Three hundred and eighty-eight elderly patients (> or =65 years) with type 2 diabetes (the mean age 72.9 years, men/women ratio 176/212) were ...

journal_title：Diabetes research and clinical practice

authors： Katakura M,Naka M,Kondo T,Komatsu M,Yamauchi K,Hashizume K,Aizawa T,Nagano Elderly Diabetes Study Group.

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:To explore the apoptotic role of amylin on human mesangial cell (MC). MATERIALS AND METHODS:Primarily cultured human MCs were applied and treated with fresh amylin preparation. Human MCs were identified by the morphology and immunofluorescence staining. The apoptotic cells were determined by ultrastructure c...

journal_title：Diabetes research and clinical practice

authors： Peng A,Liu ZH,Zhou H,Zhu MY,Li LS

更新日期：2007-10-01 00:00:00

abstract：:Epidemiological studies on diabetes mellitus revealed that the number of patients with diabetes mellitus is gradually increasing in Japan along with development of car society and westernization of food intake. Since prevalence of diabetes mellitus increases with aging, proportion of individuals with diabetes mellitus...

journal_title：Diabetes research and clinical practice

authors： Nakano T,Ito H

更新日期：2007-09-01 00:00:00

abstract：:Korean type 2 diabetics differ from Western diabetics in showing non-obese but centrally obese anthropometry and relatively more insulin secretory defects than insulin resistance. We assessed insulin secretion based on fasting serum C-peptide level and insulin resistance using the short insulin tolerance test (Kitt; r...

journal_title：Diabetes research and clinical practice

authors： Kim DJ,Song KE,Park JW,Cho HK,Lee KW,Huh KB

更新日期：2007-09-01 00:00:00

abstract：:Uncoupling protein 2 (UCP-2) is a newly identified member of the mitochondrial anion carrier family and shares 60% sequence identity with the well-characterized thermogenic UCP-1 from brown adipose tissue. Several lines of evidence suggest that UCP-2 is involved in the control of reactive oxygen species (ROS) producti...

journal_title：Diabetes research and clinical practice

authors： Kim HS,Park KG,Koo TB,Huh S,Lee IK

更新日期：2007-09-01 00:00:00

abstract：:Knowledge about the current status of diabetes management is indispensable for the improvement of diabetes management. We performed a survey to investigate the current trend of diabetes management in elderly Koreans, at eight hospitals located throughout the country. A total of 539 patients with type 2 diabetes older ...

journal_title：Diabetes research and clinical practice

authors： Noh JH,Kim SK,Cho YJ,Nam HU,Kim IJ,Jeong IK,Choi MG,Yoo HJ,Ahn YH,Bae HY,Jang HC

更新日期：2007-09-01 00:00:00

abstract：:Glucose-induced insulin secretion from beta-cells is often impaired in diabetic condition and by exposure to diabetogenic pharmacological agents. In pancreatic beta-cells, intracellular glucose metabolism regulates exocytosis of insulin granules, according to metabolism-secretion coupling in which glucose-induced mito...

journal_title：Diabetes research and clinical practice

authors： Fujimoto S,Nabe K,Takehiro M,Shimodahira M,Kajikawa M,Takeda T,Mukai E,Inagaki N,Seino Y

更新日期：2007-09-01 00:00:00

abstract：:Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in patients with diabetes. Oxidative stress has been postulated to be a major contributor to the pathogenesis of these events. There is considerable evidence that many biochemical pathways adversely affected by hyper...

journal_title：Diabetes research and clinical practice

authors： Son SM

更新日期：2007-09-01 00:00:00

abstract：:Vascular complications are the leading cause of morbidity and mortality in patients with diabetes. Four main molecular mechanisms have been implicated in glucose-mediated vascular disease. There are: glucose-induced activation of protein kinase C (PKC) isoforms; increased formation of glucose-derived advanced glycatio...

journal_title：Diabetes research and clinical practice

authors： Nishikawa T,Kukidome D,Sonoda K,Fujisawa K,Matsuhisa T,Motoshima H,Matsumura T,Araki E

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:To compare the prevalence of the Metabolic Syndrome (MetS) defined by four definitions and to determine which definition best identifies those at high cardiovascular disease (CVD) risk and with insulin resistance. METHODS:AusDiab is a population-based survey of 11,247 Australians. Participants had anthropome...

journal_title：Diabetes research and clinical practice

authors： Cameron AJ,Magliano DJ,Zimmet PZ,Welborn T,Shaw JE

更新日期：2007-09-01 00:00:00

abstract：AIMS:To develop a model for simulations of processes in the oral glucose tolerance test (OGTT), using tools of the theory of dynamic systems. METHODS:Frequent sampling OGTT was performed in 13 healthy subjects (6 males and 7 females). Subsequently, employing glucose and insulin concentration-time profiles of the subje...

journal_title：Diabetes research and clinical practice

authors： Dedík L,Durisová M,Penesová A,Miklovicová D,Tvrdonová M

更新日期：2007-09-01 00:00:00

abstract：:We used Oman's 1991 National Diabetes Survey data (n=4881) to develop a simple diabetes risk score for identification of individuals at high risk of having diabetes mellitus. The logistic regression model used included age, waist circumference, body mass index, family history of diabetes and hypertension status at the...

journal_title：Diabetes research and clinical practice

authors： Al-Lawati JA,Tuomilehto J

更新日期：2007-09-01 00:00:00

abstract：:The aim of the study was to determine the temporal changes in the prevalence of type 2 diabetes mellitus and its associated risk factors in a rural population of Bangladesh. A total of 4757 subjects age >/=20 years both male and female were enrolled randomly in a cross-sectional study in 1999. The same area and popula...

journal_title：Diabetes research and clinical practice

authors： Rahim MA,Hussain A,Azad Khan AK,Sayeed MA,Keramat Ali SM,Vaaler S

更新日期：2007-08-01 00:00:00

abstract：:We have investigated predictive value of HbA1c for hospital mortality and length of stay (LOS) in patients with type 2 diabetes admitted because of sepsis. A prospective observational study was implemented in a university hospital, 286 patients with type 2 diabetes admitted with sepsis were included. Leukocyte count, ...

journal_title：Diabetes research and clinical practice

authors： Gornik I,Gornik O,Gasparović V

更新日期：2007-07-01 00:00:00